The Melchiorre’s Group
Group Leader
Paolo Melchiorre
Postdoctoral Researchers
Jan Vilim / Will C.Hartley / Vasileios Tseliou / Diyuan Li
PhD Students
Eleni Georgiou / Davide Spinnato / Matteo Balletti / Emilien Le Saux / Laura Kqiku / Thomas H Wong / Igor Dmitriev / Florian Schiel
Visiting Postdoctoral Researchers
Yann Baumgartner / Martin Berger
Visiting PhD Student
Wei Zhou / Shuo Wu / Antonio Di Sabato / Malte Haring
Visiting Students
Asad Shehzad / Tommy Wachsmuth / Gianluca Simionato
Lab. Technician
Jose Miguel Selles Japas
Summary
The research of Prof. Melchiorre aims to connect two areas of molecular activation, photochemistry and organocatalysis, to provide new frameworks for chemical reactivity for the development of light-emitted asymmetric transformations. His group has shown that the synthetic potential of organocatalytic intermediates is not limited to the fundamental state, but can be expanded by exploring their photochemical activity, providing new synthetic routes for the preparation of chiral molecules that cannot be achieved with the traditional methodologies.
Publications
Photochemical Organocatalytic Functionalization of Pyridines via Pyridinyl Radicals
Le Saux, E.; Georgiou, E.; Dmitriev, I. A.; Hartley, W. C.; Melchiorre, P.
Am. Chem. Soc. 2022, 145 (1), 47-52
Enantioselective Biocascade Catalysis with a Single Multifunctional Enzyme
Tseliou, V.; Faraone, A.; Kqiku, L.; Vilím, J.; Simionato, G.; Melchiorre, P.
Angew. Chem. Int. Ed. 2022
Switchable Photocatalysis for the Chemodivergent Benzylation of 4-Cyanopyridines
Georgiou, E.; Spinnato, D.; Chen, K.; Melchiorre, P.; Muñiz, K.
Chem. Sci. 2022, 13, 8060-8064
MORE PUBLICATIONS
Tetrachlorophthalimides as Organocatalytic Acceptors for Electron Donor–Acceptor Complex Photoactivation
Zhou, W.; Wu, S.; Melchiorre, P.
J. Am. Chem. Soc. 2022
Lewis Base-Catalysed Enantioselective Radical Conjugate Addition for the Synthesis of Enantioenriched Pyrrolidinones
Hartley, W. C.; Schiel, F.; Ermini, E.; Melchiorre, P.
Angew. Chem. Int. Ed. 2022, 61 (26), e202204735
Photochemical organocatalytic enantioselective radical γ-functionalization of α-branched enals
Balletti, M.; Marcantonio, E.; Melchiorre, P.
Chem. Commun. 2022
Photoredox Organocatalysis for the Enantioselective Synthesis of 1,7-Dicarbonyl Compounds
Hin-Fung Wong, T.; Ma, D.; Di Sanza, R.; Melchiorre, P.
Org. Lett. 2022, 24 (8), 1695–1699
Introduction: Photochemical Catalytic Processes
Melchiorre, P.
Chem. Rev. 2022, 122 (2), 1483–1484
Photochemical Organocatalytic Benzylation of Allylic C–H Bonds
Le Saux, E.; Zanini, M.; Melchiorre, P.
J. Am. Chem. Soc. 2022, 144 (3), 1113–1118
Projects
PHOTO-N-TOOLS
New Synthetic Methods Enabled by the Photochemistry of Organic Molecules and Their Use in Drug Discovery and Bioconjugation
Ministerio de Ciencia e Innovación / PID2019-106278GB-100
PHOTO-CYCLE
Photocatalysis in Drug Discovery – Asymmetric Preparation of Bioactive Chiral Lactones and Cyclohexanols
H2020-MSCA-IF-2019 / 894795
PHOTO-ITU
Merging enantioselective isothiourea catalysis with visible-light photoactivation for the synthesis of biologically-relevant chiral molecules
H2020-MSCA-IF-2020 / 101031533
BIO-LIGHT
Photoexcitation for New-to-Nature Enzymatic Reactions
H2020-MSCA-IF-2020 / 101032077
ELECTRO-ASYMMETRIC
Electrochemical stereoselective radical cascades for accessing natural-like compounds
HORIZON-MSCA-2021-PF / Ref. 101062393
Melchiorre Research Group
AGAUR / Ref. 2021 SGR 00855
Theses Supervised
Davide Spinnato
September 7, 2022
Universitat Rovira i Virgili
Nickel and Iron Complexes for electrochemical proton and Carbon dioxide reduction
Matteo Balletti
October 10, 2022
Universitat Rovira i Virgili
POMSimulator: a Method for Understanding the Multi-Equilibria and Self-Assembly Processes of Polyoxometalates